Two sample MR report
SPATA20_Alveolar Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 4 | -0.0597525 | 0.2196021 | 0.8110654 |
| Weighted median | 4 | 0.0194668 | 0.0095133 | 0.0407301 |
| Inverse variance weighted | 4 | 0.0196435 | 0.0084111 | 0.0195208 |
| Simple mode | 4 | 0.0191767 | 0.0127406 | 0.2293483 |
| Weighted mode | 4 | 0.0190939 | 0.0126267 | 0.2276787 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.0155932 | 2 | 0.9922337 |
| Inverse variance weighted | 0.1465000 | 3 | 0.9857253 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0578227 | 0.159815 | 0.7521443 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 7.03e-05 | 0 | TRUE | 0.4257706 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
